Basic Information
VIS ID
TVIS44003359
Fusion event
HTLV-1-IL5RA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p26.2
Reference genome
GRCh37/hg19
Start
3137453/3095769 (Hg38)
End
3137453/3095769 (Hg38)
Orient
-
Location type
Intronic
Target gene
IL5RA
miRNAs that regulate target gene
hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-31-5p ; hsa-mir-6827-5p ; hsa-mir-505-5p ; hsa-mir-1273f ; hsa-mir-6871-5p ; hsa-mir-6873-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-3941 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p
Nearest miRNA
hsa-let-7g/Downstream/2154408;
Nearest TSS
ENST00000440867/Upstream/26527; ENST00000465998/Downstream/14211;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/995669, chr3-CpG: 95/Downstream/30871
Upstream sequence
CAAGGATTACTACTCCAAATAGAGTTGAATGCTTGAATTACTTCCCCCCCTCAGCTCATTGCAAGACTCACCCACCATCCCCCTTTACTACTCAAGTTGT
Downstream sequence
ACCAGGCCCAGAATAAACCTGACCACTGAGAGAACATTTCcctggaccttccaccaagccttgcctcttcccagtaggtatgtggccctgaacaaatcac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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