VISDB - VIS Detail

Basic Information

VIS ID

TVIS44003367

Fusion event

HTLV-1-GABRB1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr4

Cytoband

p12

Reference genome

GRCh37/hg19

Start

47223435/47221418 (Hg38)

End

47223435/47221418 (Hg38)

Orient

Location type

Intronic

Target gene

GABRB1

miRNAs that regulate target gene

hsa-mir-203a-3p ; hsa-mir-3121-3p ; hsa-mir-5582-3p ; hsa-mir-411-5p ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-4790-3p ; hsa-mir-5586-3p ; hsa-mir-100-3p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-5095 ; hsa-mir-7151-3p ; hsa-mir-873-3p ; hsa-mir-4329 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-3622a-5p ; hsa-mir-4438 ; hsa-mir-4446-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-1224-3p ; hsa-mir-5003-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-1251-3p ; hsa-mir-31-3p ; hsa-mir-4524b-3p ; hsa-mir-7150 ; hsa-mir-885-3p ; hsa-mir-4307 ; hsa-mir-129-5p ; hsa-mir-1271-5p ; hsa-mir-182-5p ; hsa-mir-96-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-4420 ; hsa-mir-653-3p ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-1208 ; hsa-mir-6760-3p ; hsa-mir-2355-3p ; hsa-mir-676-3p ; hsa-mir-4778-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-3646 ; hsa-mir-3140-5p ; hsa-mir-1910-3p ; hsa-mir-2682-5p ; hsa-mir-34b-5p ; hsa-mir-4423-3p ; hsa-mir-449c-5p ; hsa-mir-6511a-5p ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-8068 ; hsa-mir-940

Nearest miRNA

hsa-mir-12113/Upstream/6719299; hsa-mir-1243/Downstream/431251;

Nearest TSS

ENST00000502981/Upstream/189785; ENST00000507889/Downstream/242247;

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/188495, chr4-CpG: 21/Downstream/204257

Upstream sequence

taggatacaaccaagttaagtgttcaaatttttatccccaTTCTAAGCACCTACAAGTGACATTGCTTTGCCCAATTATATAGAAACTTAATCAATATTT

Downstream sequence

ATCAAATGGAATTGTTACTGAACTAATTCAGTTCACCTGGGGCTTGCCACATGATCCTTTCCTTTATTGCTTCATTTATCAGAAGTGGCTTATGATTTTC

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.