Basic Information
VIS ID
TVIS44003370
Fusion event
HTLV-1-SNX25 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
186187872/185266718 (Hg38)
End
186187872/185266718 (Hg38)
Orient
-
Location type
Intronic
Target gene
SNX25
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-12113/Upstream/328278;
Nearest TSS
ENST00000502981/Upstream/56557; ENST00000513433/Downstream/29109;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/55976, chr4-CpG: 118/Downstream/129271
Upstream sequence
cccaaagtgctgggattacaggtgtgagccaccacgcccggccTTAATTTTGATAGATTTGTTAGCAACTTGAGTTCCAAATGACTTCCCTTCATGATTC
Downstream sequence
TTTTACATTTCACTTATTTATTAAAATGACAACTTGATTATAGCCATGGATGATAACATATTTGGAGGGATAGGCAGCTGTATGTGTGCATGTGTGTACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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