Basic Information
VIS ID
TVIS44003392
Fusion event
HTLV-1-CREM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
35444538/35155610 (Hg38)
End
35444538/35155610 (Hg38)
Orient
+
Location type
Intronic
Target gene
CREM
miRNAs that regulate target gene
hsa-let-7c-5p ; hsa-mir-3117-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-1288-3p ; hsa-mir-4312 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-8083 ; hsa-mir-3169 ; hsa-mir-4759 ; hsa-mir-562
Nearest miRNA
hsa-mir-1265/Upstream/75930; hsa-mir-107/Downstream/485562;
Nearest TSS
ENST00000439456/Upstream/7209; ENST00000497686/Downstream/11906;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/27853, chr10-CpG: 23/Downstream/59270
Nearest cancer related gene
CREM(TSG, No orient, 0)
Upstream sequence
ataaaaGATAATGAATAACAAAAAAAATAGGCTAGACATTGAAATTTGAAAAAAGAAACATTAATTTTATAGTTTCTTTTTTGAGTAAGACTTAGGGAtt
Downstream sequence
cttttcttttcttttcttttctttttttttTTGTAGAGATGggagtctcgctctgtcacctaggctggagtgcagtggcacaatgtcagctaactgcaac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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