Basic Information
VIS ID
TVIS44003425
Fusion event
HTLV-1-USP25 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17213113/15840794 (Hg38)
End
17213113/15840794 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
USP25
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-101-3p ; hsa-mir-27a-3p ; hsa-mir-454-5p ; hsa-mir-200c-3p ; hsa-mir-297 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4666a-5p ; hsa-mir-27b-3p ; hsa-mir-513a-5p ; hsa-mir-6832-5p ; hsa-mir-16-1-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-411-5p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-mir-144-3p
Nearest miRNA
hsa-mir-10396a/Upstream/2116520; hsa-let-7c/Downstream/698295;
Nearest TSS
ENST00000624081/Upstream/15784; ENST00000449491/Downstream/1724;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/110310, chr21-CpG: 138/Downstream/1671694
Upstream sequence
ATTTGACATGTGTTGATCAGATAACATTACTCTTGGTCCTAAGAACCAATTTTACAAAGATTCTAGGTTTCAGTGGGTCATTAGACCAATGTCAGACCAG
Downstream sequence
ATGGATTTATTGCTTTAAGTTCACATCCAATTATTAACCGTTGACATTATCTGCTATGGTGAAGAGAGGAAGAGTGCCAAACACAAGGAAAAGTTTTATC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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