Basic Information
VIS ID
TVIS44003453
Fusion event
HTLV-1-TBC1D31 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
124059947/123047707 (Hg38)
End
124059947/123047707 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
TBC1D31
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-615-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-12123/Upstream/3722442; hsa-mir-10400/Downstream/168081;
Nearest TSS
ENST00000518652/Upstream/5284; ENST00000518684/Downstream/24973;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/5214, chr8-CpG: 44/Downstream/24955
Nearby gene
DERL1(-5284) ;
Upstream sequence
atatataAATTGCTTTCACCAAAAACAGGAAGAGccaacctgcataatatagcaagaccccatctctacaaaaaaagaattttttttaattagcaagcat
Downstream sequence
tatggtatgtgcctatagtcccagctacttgggaggctgaagtgggaggatcacctgagcccaggaggtcgaggctgcagcaagccatgatcacaacact
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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