Basic Information
VIS ID
TVIS44003455
Fusion event
HTLV-1-TLE3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
70387968/70095629 (Hg38)
End
70387968/70095629 (Hg38)
Orient
-
Location type
Exonic
Target gene
TLE3
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-505-3p ; hsa-mir-196b-5p ; hsa-mir-222-3p ; hsa-mir-34a-5p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-18a-5p ; hsa-mir-1260b ; hsa-mir-6858-5p ; hsa-mir-8085 ; hsa-mir-4689 ; hsa-mir-6731-5p ; hsa-mir-765 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-7160-5p ; hsa-mir-6133 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6760-5p ; hsa-mir-4786-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-6873-5p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-6739-5p ; hsa-mir-767-5p ; hsa-mir-648 ; hsa-mir-1911-3p ; hsa-mir-595 ; hsa-mir-5583-5p ; hsa-mir-4311 ; hsa-mir-3129-3p ; hsa-mir-141-5p ; hsa-mir-3163 ; hsa-mir-548c-3p ; hsa-mir-744-5p
Nearest miRNA
hsa-mir-10393/Upstream/16161; hsa-mir-11181/Downstream/2491588;
Nearest TSS
ENST00000557528/Upstream/41; ENST00000558226/Downstream/321;
Nearest CpG islands
chr15-CpG: 409/Target, None/Upstream, None/Downstream
Upstream sequence
ccggggtcggcgccccaaccgccccccaggcccgcggccgcATCTCACCATCACATAATGGCGCTGCATCTCCGTCTTCTCGTTTGCCAGCTTGTCGTAC
Downstream sequence
TCCACTTTGAGGCTGCGAGGGCAGGAGGAGCCGGCTCAGGCGTGGCGCCTGGACAGCCTCCTCTGAGGCCCCGACCCAAGGGCCTCTAGAGCCACTTTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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