Basic Information
VIS ID
TVIS44003495
Fusion event
HTLV-1-MCOLN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
85461035/84995352 (Hg38)
End
85461035/84995352 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
MCOLN2
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-601 ; hsa-mir-4641 ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-25-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-363-3p ; hsa-mir-365a-3p ; hsa-mir-365b-3p ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-1273f ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-1304-3p ; hsa-mir-143-3p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4534 ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-6514-5p ; hsa-mir-8055 ; hsa-mir-8082
Nearest miRNA
hsa-mir-101-1/Upstream/7935150; hsa-mir-11399/Downstream/138442;
Nearest TSS
ENST00000473358/Upstream/65508; ENST00000528899/Downstream/1588;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/101848, chr1-CpG: 86/Downstream/1550
Upstream sequence
gagcacatgctgttggaaaaatggcaccaatagacttgctggacacagggttgccacaaaccttcaatttgtaaaataaaataaaattgaattaaatgca
Downstream sequence
gtatctacaaagtgcaataaagcaaagaacaataaaacaaggtatgcctgCACTTTTTTCTATGAACCCCTTAACATGTGACACAAGAGCTCACTAAAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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