Basic Information
VIS ID
TVIS44003517
Fusion event
HTLV-1-XKR6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
10991373/11133863 (Hg38)
End
10991373/11133863 (Hg38)
Orient
-
Location type
Intronic
Target gene
XKR6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-218-5p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-4795-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-7850-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-122-5p ; hsa-mir-5582-3p ; hsa-mir-504-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-4455 ; hsa-mir-3924 ; hsa-mir-6074
Nearest miRNA
hsa-mir-124-1/Upstream/98561; hsa-mir-10400/Downstream/1585269;
Nearest TSS
ENST00000518652/Upstream/66774; ENST00000602443/Downstream/66971;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/62162, chr8-CpG: 79/Downstream/66312
Upstream sequence
CCCTAAGAAATGTCAGGTCTTACAACCACCCCACATCCAAAACATAATTAACTCTATGCTTTCCATTATATCATAGACCTATtcagaccatgtcggctcc
Downstream sequence
tactaaaacccagcaagacttcctcccatttatggaataaagtctaaaccccacaactttgtctatggtgctattcatgagctggtctcttatgtttttg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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