Basic Information
VIS ID
TVIS44003524
Fusion event
HTLV-1-HS6ST3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
97032195/96379941 (Hg38)
End
97032195/96379941 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
HS6ST3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-5589-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-574-5p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-592 ; hsa-mir-513a-5p ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-597-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-4445-5p ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-6767-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-1297/Upstream/3889721; hsa-mir-1267/Downstream/47288;
Nearest TSS
ENST00000623511/Upstream/289102; ENST00000620595/Downstream/452547;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/288033, chr13-CpG: 35/Downstream/614199
Upstream sequence
ATATTTCTTTCTAGAAATATTTCTAGAATTGTGGCAACAGCCTAGTGCTTAGATGAGCACTCTTTTTTTCAGAAGTGAATCAAGAGGAAAAAAGGAAGAA
Downstream sequence
ATTCTAAAACCAGTTTCTATTAAAATGATAAGATGTTTGGGGTTTCTGTGAaatcacatagttttataactaaaactgctttgagagaaaggctggattc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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