Basic Information
VIS ID
TVIS44003554
Fusion event
HTLV-1-ATP8B4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
50277730/49985533 (Hg38)
End
50277730/49985533 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP8B4
miRNAs that regulate target gene
hsa-mir-5585-3p ; hsa-mir-6857-3p ; hsa-mir-6761-5p ; hsa-mir-4494 ; hsa-mir-208a-5p ; hsa-mir-208b-5p ; hsa-mir-4499 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-10393/Upstream/816380; hsa-mir-11181/Downstream/374796;
Nearest TSS
ENST00000557528/Upstream/54299; ENST00000559938/Downstream/59141;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/364248, chr15-CpG: 86/Downstream/196592
Upstream sequence
GTTCCCCAACTAAATGTCTTAAGACTTAGAGGTTTTGTGACATCCATTTGTTCATCTCCGACACGGACGAAGCCAACCACTAATTCTTCTGTTTGCCAGC
Downstream sequence
ATTCTAATTAAGCTTTCTGCTAACATTTGTGACCAGACTAAAGTCAATGCAGGCATGCTCTGCTTTACAAACATCCAGTTGATAAGGTCTCCTGCAAGTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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