Basic Information
VIS ID
TVIS44003558
Fusion event
HTLV-1-SLIT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
98912541/97152784 (Hg38)
End
98912541/97152784 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SLIT1
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-4266 ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-6508-3p ; hsa-mir-541-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-570-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-141-5p ; hsa-mir-1324 ; hsa-mir-629-3p ; hsa-mir-4713-5p ; hsa-mir-1197 ; hsa-mir-1224-5p ; hsa-mir-3064-3p ; hsa-mir-4722-3p ; hsa-mir-4751 ; hsa-mir-5004-5p ; hsa-mir-6727-3p
Nearest miRNA
hsa-mir-107/Upstream/324020; hsa-mir-1287/Downstream/723029;
Nearest TSS
ENST00000439456/Upstream/50028; ENST00000490980/Downstream/2649;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/109107, chr10-CpG: 108/Downstream/32521
Upstream sequence
ccgtaaacgtaacacatgcttcttaaagaacatctgagacacagaagagaaaaaagccacccacagacaatccctgttggcattttccaggtatgttttc
Downstream sequence
atgcattatttagagtgatttatcaagtggtcatattgtcaatgcagtttggaatcctggcttttgatatcaaacacatgtatctgcattacttgacatc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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