Basic Information
VIS ID
TVIS44003566
Fusion event
HTLV-1-PDE3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
14815986/14794440 (Hg38)
End
14815986/14794440 (Hg38)
Orient
-
Location type
Intronic
Target gene
PDE3B
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-93-5p ; hsa-mir-16-5p ; hsa-mir-562 ; hsa-mir-3119 ; hsa-mir-4735-5p ; hsa-mir-5683
Nearest miRNA
hsa-mir-210/Upstream/2630673; hsa-let-7a-2/Downstream/1175093;
Nearest TSS
ENST00000527297/Upstream/5501; ENST00000324229/Downstream/91401;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/149312, chr11-CpG: 68/Downstream/96914
Upstream sequence
gagtctcactctgttgcccaggctggagtgcagtggcacgatctctgcccactgcagtctctgcctcctgggatcaagcaattcttcctcaacctcctga
Downstream sequence
gtagttgggactacaggcacatgccaccatgcccagctaatttttgtatttttagtagagacggggtttcaccatgttggccaggctggtctcgaactcc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate