Basic Information
VIS ID
TVIS44003584
Fusion event
HTLV-1-DIAPH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
96098781/96843782 (Hg38)
End
96098781/96843782 (Hg38)
Orient
-
Location type
Intronic
Target gene
DIAPH2
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-let-7f-2/Upstream/1780556; hsa-mir-105-1/Downstream/9796032;
Nearest TSS
ENST00000429181/Upstream/158765; ENST00000373040/Downstream/40126;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/158415, chrX-CpG: 23/Downstream/3095554
Upstream sequence
taactactctcgccccactacacaggaattcaagagcccagctcctccctgcggcaaaaggcaggaacttccttggctcaaccctgctctcccagtatgc
Downstream sequence
atgctggtggaagattatccgtggaccctccccgttatctgcctcctgcatctatcaGGACCTTAGGAAGcctgttttactgaatgtatgaaagctttta
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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