Basic Information
VIS ID
TVIS44003601
Fusion event
HTLV-1-CARMIL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
25514667/25514439 (Hg38)
End
25514667/25514439 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6C
Target gene
CARMIL1
miRNAs that regulate target gene
hsa-mir-149-5p
Nearest miRNA
hsa-mir-3691/Upstream/6942559; hsa-mir-10398/Downstream/1633187;
Nearest TSS
ENST00000381078/Upstream/19318; ENST00000476458/Downstream/95683;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/234777, chr6-CpG: 21/Downstream/137791
Upstream sequence
agtttgagaccagcctggccaacatggtgaaaccctgtctctactaaaaatacaaaaattagccaggcatggtggtgggcgcctgtaatcccagctactc
Downstream sequence
ggtaggctgaggcaggagaatcacttgaatctgggaggcggaggttgcagtaagctgagattatgccactgcagcactccagcttggggggacagagcga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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