Basic Information
VIS ID
TVIS44003603
Fusion event
HTLV-1-DACT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
168694729/168294049 (Hg38)
End
168694729/168294049 (Hg38)
Orient
+
Location type
Intronic
Target gene
DACT2
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-193b-3p
Nearest miRNA
hsa-mir-10398/Upstream/1296137; hsa-mir-4644/Downstream/2036712;
Nearest TSS
ENST00000381078/Upstream/51035; ENST00000568306/Downstream/25661;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/8265, chr6-CpG: 27/Downstream/13409
Upstream sequence
gacgtccccagggatgacagagattacttgtgagtagaggaggtccatccaacacgcacgtctgctactgctctttgcctccccgtccccacagagcacc
Downstream sequence
cacgatgcccatgagcacagacccgcgatggcagttgtgcagctagacccgaagcacacagacagtgagcatggagcacttaccactgagcagaaaggga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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