Basic Information
VIS ID
TVIS44003610
Fusion event
HTLV-1-PPARGC1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
24457561/24455938 (Hg38)
End
24457561/24455938 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
PPARGC1A
miRNAs that regulate target gene
hsa-mir-23a-3p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-421 ; hsa-mir-425-3p ; hsa-mir-378a-5p ; hsa-let-7b-5p ; hsa-mir-130b-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4775 ; hsa-mir-3124-3p ; hsa-mir-5011-5p ; hsa-mir-32-3p ; hsa-mir-5585-3p ; hsa-mir-3941 ; hsa-mir-8064 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-485-3p ; hsa-mir-485-5p ; hsa-mir-130a-3p ; hsa-mir-4311 ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4668-5p
Nearest miRNA
hsa-mir-12113/Upstream/1940553; hsa-mir-1243/Downstream/64254;
Nearest TSS
ENST00000502981/Upstream/551849; ENST00000569621/Downstream/74141;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1939513, chr4-CpG: 266/Downstream/14139
Nearby gene
MIR573(-64254) ;
Upstream sequence
acttaccaacctccagaactgtaagaaataaatctctgttttttataaattacccagtctgtggtattctgttatagcaacacaaaatgaactaagataA
Downstream sequence
TTATCTAGCTGAGCTTGGCAGATAGGCTGCTTTAGACACTATCTGCCTCTTTGCTCAAAGAATCTGTGAGCTACTGGTGGCAGCCAATGTCACACTCATG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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