Basic Information
VIS ID
TVIS44003649
Fusion event
HTLV-1-PLPPR5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
99358817/98893261 (Hg38)
End
99358817/98893261 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1M
Target gene
PLPPR5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/847090; hsa-mir-11399/Downstream/1387980;
Nearest TSS
ENST00000473358/Upstream/231038; ENST00000425113/Downstream/111015;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/231106, chr1-CpG: 74/Downstream/111115
Upstream sequence
ATATGTAGTACCTTTACAAATAATCATTAGCTTATATGCTGAATGTTGAAGTTGCAAAACATCCAGCATTATTAAACTAAGTTTTATGTATTATTACACA
Downstream sequence
ATTTTTGCTGCTAATTACATATTTTATTCAATAATCTTAATTATACAAATAGATTAAAATGTTATACCTGCTTTATTCAAAATTAACTCTGAAATTTGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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