Basic Information
VIS ID
TVIS44003655
Fusion event
HTLV-1-RUFY2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
70155290/68395533 (Hg38)
End
70155290/68395533 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
RUFY2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-425-5p ; hsa-mir-196a-5p ; hsa-mir-20a-5p ; hsa-mir-1205 ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-127-5p ; hsa-mir-593-5p ; hsa-mir-767-5p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-6715b-5p ; hsa-mir-3925-5p ; hsa-mir-4269 ; hsa-mir-509-5p ; hsa-mir-4418 ; hsa-mir-509-3-5p ; hsa-mir-4796-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-3149 ; hsa-mir-4477b ; hsa-mir-1231 ; hsa-mir-568 ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-mir-4724-3p ; hsa-let-7a-3p ; hsa-mir-409-5p ; hsa-mir-4720-3p ; hsa-mir-6876-3p ; hsa-mir-626 ; hsa-mir-3120-5p ; hsa-mir-29b-1-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-6782-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428
Nearest miRNA
hsa-mir-1265/Upstream/992123; hsa-mir-107/Downstream/3395214;
Nearest TSS
ENST00000439456/Upstream/14277; ENST00000373644/Downstream/11417;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/62717, chr10-CpG: 116/Downstream/10916
Upstream sequence
TTTATTAGAGTTGAATTTTCAATCCTCGGATTTATTAAGACCCTTGGGATAAAGACTAAGGTAGAAAATGAACATATGCAACATTTCAAAGTCCATGTTC
Downstream sequence
AAGTCAATGCATTTGATAGGTATATTATAAATCTTAATAGATAATCATCAATTAAAGACACTTTGGGATATCTACATTCTAAAAACTGTTGAAAAAGAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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