Basic Information
VIS ID
TVIS44003657
Fusion event
HTLV-1-ZDHHC17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
77222703/76828923 (Hg38)
End
77222703/76828923 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZDHHC17
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-30b-5p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-5689 ; hsa-mir-4643 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7i/Upstream/7244100; hsa-mir-1178/Downstream/2590334;
Nearest TSS
ENST00000382841/Upstream/31404; ENST00000549010/Downstream/11136;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/64298, chr12-CpG: 68/Downstream/49874
Upstream sequence
gattcaggggttacatgtgaaggtttgttgtagggatatattgtgtaatggagaaaagaacaagcatcctcatttcaaaaaatgggtaaaggacacagac
Downstream sequence
acagacagacatttctccaaggacatacaagtggccaaacgtgaaaaaatgttggacatcactaatcatcagagaaatgcaaattaaaactacaatttca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate