Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene2317467822867052229810632298319223039673229786852298139622974201229754282297300122973800229778012297840022989856229902912297560122975800229896782298982723020865
Basic Information
VIS ID
TVIS44003662
Fusion event
HTLV-1-TUBGCP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
22852201/23020865 (Hg38)
End
22852201/23020865 (Hg38)
Orient
+
Location type
Intronic
Target gene
TUBGCP5
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-6836-3p ; hsa-mir-6749-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-6829-3p ; hsa-mir-1297 ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-2116-3p ; hsa-mir-5697 ; hsa-mir-500a-5p
Nearest miRNA
hsa-mir-1268a/Upstream/795536; hsa-mir-10393/Downstream/176962;
Nearest TSS
ENST00000557528/Upstream/11984; ENST00000562295/Downstream/3511;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/39735, chr15-CpG: 87/Downstream/18291
Upstream sequence
gccgagatcgcaccactacactccagcctgggcaacagagcaagactctgtctcaaaaaaggtagccagctctggaggcacatgcctatggtcccaggta
Downstream sequence
ctcgagaggctaaggcaggaagatggcttgagtgtggaaggtcaaggctgcagtgagccatgtttgtgccactgcactccagcttgggtaacagagcaag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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