VISDB - VIS Detail

Basic Information

VIS ID

TVIS44003662

Fusion event

HTLV-1-TUBGCP5 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr15

Cytoband

q11.2

Reference genome

GRCh37/hg19

Start

22852201/23020865 (Hg38)

End

22852201/23020865 (Hg38)

Orient

+

Location type

Intronic

Target gene

TUBGCP5

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-6836-3p ; hsa-mir-6749-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-6829-3p ; hsa-mir-1297 ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-2116-3p ; hsa-mir-5697 ; hsa-mir-500a-5p

Nearest miRNA

hsa-mir-1268a/Upstream/795536; hsa-mir-10393/Downstream/176962;

Nearest TSS

ENST00000557528/Upstream/11984; ENST00000562295/Downstream/3511;

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/39735, chr15-CpG: 87/Downstream/18291

Upstream sequence

gccgagatcgcaccactacactccagcctgggcaacagagcaagactctgtctcaaaaaaggtagccagctctggaggcacatgcctatggtcccaggta

Downstream sequence

ctcgagaggctaaggcaggaagatggcttgagtgtggaaggtcaaggctgcagtgagccatgtttgtgccactgcactccagcttgggtaacagagcaag

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.