Basic Information
VIS ID
TVIS44003669
Fusion event
HTLV-1-TRIM39 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
30311251/30343474 (Hg38)
End
30311251/30343474 (Hg38)
Orient
+
Location type
UTR3
Target gene
TRIM39
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-6866-5p ; hsa-mir-1827 ; hsa-mir-4742-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6515-3p ; hsa-mir-4469 ; hsa-mir-877-3p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-1470
Nearest miRNA
hsa-mir-3143/Upstream/3195786; hsa-mir-10398/Downstream/240858;
Nearest TSS
ENST00000381078/Upstream/13945; ENST00000466327/Downstream/1657;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/16180, chr6-CpG: 36/Downstream/1586
Upstream sequence
TTGTTTGTTGCCATCCCTCACCCTTTGCCATTTCCCTTTTCAGAGAATGTAAATGATTTTCATGTTAGGCCAAAATAAACAACTTATAGGGTACATATGT
Downstream sequence
TGTCATAAAAGGTAAAAGTGATGCATGCCAAACCAAACTAAACCAATTTGGATTATCTGCTATTCGGGTAATCTTCACAGAAATGACTGAGAGAAGAATC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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