Basic Information
VIS ID
TVIS44003674
Fusion event
HTLV-1-SLK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
105727958/103968200 (Hg38)
End
105727958/103968200 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SLK
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-let-7c-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-107/Upstream/573799; hsa-mir-202/Downstream/79889;
Nearest TSS
ENST00000439456/Upstream/999; ENST00000474260/Downstream/39998;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/532, chr10-CpG: 46/Downstream/153491
Upstream sequence
AAGAGCGATTGGAAAAGGAGACAGGGTTATAAAGTCTACTCTTTCAAACTTCAAAGGAAATGAGAGTGTTCTTTAATTTATAGGAGGGGTCTGGTTGTGC
Downstream sequence
CCTTCAAGTATTTTAGAATGAGAAACTCATTGCACTTTGCAGTGGATTTGTCTACTGACTGCATTCGCGTGCATGCTTGTACTCCAACAGTTCTGTTTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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