Basic Information
VIS ID
TVIS44003681
Fusion event
HTLV-1-PATZ1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31735493/31339507 (Hg38)
End
31735493/31339507 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
PATZ1
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-942-5p ; hsa-mir-7114-5p ; hsa-mir-4443 ; hsa-mir-516b-5p ; hsa-mir-3191-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6089 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-4636 ; hsa-mir-3680-5p ; hsa-mir-29b-3p ; hsa-mir-1285-3p ; hsa-mir-3187-5p ; hsa-mir-3620-3p ; hsa-mir-3914 ; hsa-mir-4731-5p ; hsa-mir-5189-5p ; hsa-mir-5589-5p ; hsa-mir-612 ; hsa-mir-621 ; hsa-mir-6721-5p ; hsa-mir-6776-3p ; hsa-mir-6860 ; hsa-mir-873-5p
Nearest miRNA
hsa-mir-1286/Upstream/179388; hsa-let-7a-3/Downstream/281960;
Nearest TSS
ENST00000624155/Upstream/4158; ENST00000614284/Downstream/3778;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/48122, chr22-CpG: 213/Downstream/5552
Nearest cancer related gene
PATZ1(OG, No orient, 0)
Upstream sequence
AGTCCAAAGTCTAGGCACAGCAGAAGTTCAGACAACACAGAACATGAAAGAGCCTGGTCACACAACCCAGGAGAGAAGGGGCGGAGGGAGACAGATCTCA
Downstream sequence
AAGGGAACATCCAGAACTTCCATGCTGGGGTGTCAGGAGAAGAGCATTCTTTGTCCTAGAGACAGGGAGAAGACAGAGGGACGCTGATGGGAAGAGAGTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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