Basic Information
VIS ID
TVIS44003687
Fusion event
HTLV-1-MAP3K5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
136994454/136673316 (Hg38)
End
136994454/136673316 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAP3K5
miRNAs that regulate target gene
hsa-mir-769-3p ; hsa-mir-20a-5p ; hsa-mir-218-5p ; hsa-mir-1303 ; hsa-mir-5191 ; hsa-mir-4753-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-130b-5p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-4517 ; hsa-mir-425-5p ; hsa-mir-301a-3p ; hsa-mir-19a-3p ; hsa-mir-1224-3p ; hsa-mir-4775 ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-10398/Upstream/1434060; hsa-mir-1202/Downstream/1761897;
Nearest TSS
ENST00000381078/Upstream/44144; ENST00000367756/Downstream/119202;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/122309, chr6-CpG: 172/Downstream/118222
Upstream sequence
gacccaacccgactcaactgcatttgttgaagtaatcagcttcttaccctatctggctaacagaggaaaaggagaatctctgtgagtgaaaataaaatca
Downstream sequence
tctccaagtctcaatagttttttaatacaaaatgtctgggatacgagacatgcaaagagccagcaagttgtgaccaataaacaaaagcaaacacacacaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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