Basic Information
VIS ID
TVIS44003698
Fusion event
HTLV-1-SARM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
26711921/28384902 (Hg38)
End
26711921/28384902 (Hg38)
Orient
+
Location type
Exonic
Target gene
SARM1
miRNAs that regulate target gene
hsa-mir-4691-3p ; hsa-mir-218-5p ; hsa-mir-4539 ; hsa-mir-146a-3p ; hsa-mir-6777-3p ; hsa-mir-4714-5p ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p
Nearest miRNA
hsa-mir-1180/Upstream/24168; hsa-mir-10226/Downstream/476467;
Nearest TSS
ENST00000595228/Upstream/76; ENST00000580711/Downstream/198;
Nearest CpG islands
chr17-CpG: 78/Target, None/Upstream, None/Downstream
Upstream sequence
AGCGAAGCCCTTCCTGACACCCGACTCCTCCCCCAGGAGCAGCAGGTGGATGGCGACCTGCTTCTGCGGCTCACGGAGGAGGAACTCCAGACCGACCTGG
Downstream sequence
GCATGAAATCGGGCATCACCCGCAAGAGGTACGGAGCCTCCTGCCCGCCGGACCCCAGCTAGGTCTAAATAAGCTCCCCCTCCGCCCACAGCCCGTCCGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate