Basic Information
VIS ID
TVIS44003708
Fusion event
HTLV-1-ZNF680 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
63964550/64504172 (Hg38)
End
63964550/64504172 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
ZNF680
miRNAs that regulate target gene
hsa-mir-6807-5p ; hsa-mir-548aw ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3682-3p ; hsa-mir-3145-3p ; hsa-mir-3163 ; hsa-mir-4676-5p ; hsa-mir-575 ; hsa-mir-1252-3p ; hsa-mir-3662 ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-4766-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-6826-5p ; hsa-mir-4519 ; hsa-mir-4724-5p ; hsa-mir-548e-5p ; hsa-mir-26b-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-1183/Upstream/883003; hsa-mir-10399/Downstream/174892;
Nearest TSS
ENST00000635602/Upstream/190143; ENST00000360117/Downstream/40047;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/39809, chr7-CpG: 87/Downstream/65352
Nearby gene
ZNF680(-15705) ;
Upstream sequence
TTTTAAATAAGAATATTGTGAAGTTATTCTGTCAATAGAATACTATTATGACCTCATACTAATAGTCTCATCTATAGTTATGCAATACCAAATGCTTTTT
Downstream sequence
ATTAAAAGTTGCATTTTAAATAATTATTCCATTTATATTACCCTCTTTCACTATTTCAATGCCTTCTTCCGTTTATATCAGTGGAAAACAGGCTAGCTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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