Basic Information
VIS ID
TVIS44003710
Fusion event
HTLV-1-TRPM3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
73850305/71235389 (Hg38)
End
73850305/71235389 (Hg38)
Orient
+
Location type
Intronic
Target gene
TRPM3
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-4433b-5p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-6778-3p ; hsa-mir-532-3p ; hsa-mir-1281 ; hsa-mir-1224-3p ; hsa-mir-6814-5p ; hsa-mir-4761-5p
Nearest miRNA
hsa-mir-101-2/Upstream/425305; hsa-let-7a-1/Downstream/12734359;
Nearest TSS
ENST00000422679/Upstream/113791; ENST00000473252/Downstream/211446;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/815080, chr9-CpG: 50/Downstream/211208
Nearby gene
TRPM3(-113791) ;
Upstream sequence
cccagttattctccagaagtttaccctgatttgtcaacattgcatatgtcactatttgaaactgtattatgcattttttacgctttattgtctgtctccc
Downstream sequence
acactagaccatgaggcccatgatcatggagactttctcctgttcactatgtatccccagtgcctagtacatactgggtaatcaatatatttatttattg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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