Basic Information
VIS ID
TVIS44003713
Fusion event
HTLV-1-TP73 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.32
Reference genome
GRCh37/hg19
Start
3584527/3667963 (Hg38)
End
3584527/3667963 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
TP73
miRNAs that regulate target gene
hsa-mir-193a-5p ; hsa-mir-205-5p ; hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-4750-3p ; hsa-mir-548at-5p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-12136/Upstream/107173; hsa-mir-101-1/Downstream/2194709;
Nearest TSS
ENST00000473358/Upstream/15202; ENST00000604194/Downstream/809;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/14891, chr1-CpG: 40/Downstream/22569
Nearest cancer related gene
TP73(TSG, No orient, 0)
Upstream sequence
GGAATAGCTTTGCAACCCTTGTGTTACGGTGCACAGGTGTGCAAAAATTCTCCTTGAACTCCCCCTTCAGTGTCCCCCCAGGGCTCATGGCCACTGTCAC
Downstream sequence
TCTGTGCTAGTTGCTCTTCAGACCAGGGAACAGACTTGGCCATGGCTATGGCCAGGGTCCAGCTGCTATTGCTCCTCCTGTCACCCACCCACCTTTTGTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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