Basic Information
VIS ID
TVIS44003715
Fusion event
HTLV-1-COPA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
160308344/160338554 (Hg38)
End
160308344/160338554 (Hg38)
Orient
-
Location type
Intronic
Target gene
COPA
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-744-5p ; hsa-mir-421 ; hsa-mir-92b-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-23b-3p ; hsa-mir-10a-5p ; hsa-mir-1260b ; hsa-mir-127-5p ; hsa-mir-3591-5p ; hsa-mir-376b-3p ; hsa-mir-376a-3p ; hsa-mir-7153-5p ; hsa-mir-142-3p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-539-5p ; hsa-mir-4712-3p ; hsa-mir-3976 ; hsa-mir-648 ; hsa-mir-4517 ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4634 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-4746-3p ; hsa-mir-4695-3p
Nearest miRNA
hsa-mir-101-1/Upstream/438475; hsa-mir-1182/Downstream/888632;
Nearest TSS
ENST00000473358/Upstream/28032; ENST00000465223/Downstream/1654;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/75893, chr1-CpG: 38/Downstream/4584
Upstream sequence
CCTTTTTATGAATTAAATTTCACTGGTTCGGTTTGACACATAGACTTAATGAAAACAACTAAAGGAAGTAAACAGAGGAAATTTTGATTTATTTTTATAG
Downstream sequence
GTTGCTAGTCTCTGGCTCTAACTTTTGCTATTATGATAGTCAGTTGTCTTTAAAGAATTGCCTATATTCTGTCTGCTTCCTCATTTCACACTAAGGCCTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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