Basic Information
VIS ID
TVIS44003721
Fusion event
HTLV-1-UBASH3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
122617288/122746580 (Hg38)
End
122617288/122746580 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBASH3B
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-200a-3p ; hsa-mir-491-3p ; hsa-mir-192-3p ; hsa-mir-1227-3p ; hsa-mir-4275 ; hsa-mir-586 ; hsa-mir-3662 ; hsa-mir-455-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-486-5p ; hsa-mir-4797-5p
Nearest miRNA
hsa-let-7a-2/Upstream/594272; hsa-mir-3167/Downstream/634860;
Nearest TSS
ENST00000527297/Upstream/37318; ENST00000533451/Downstream/27516;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/89809, chr11-CpG: 51/Downstream/136098
Upstream sequence
tcaatcaataaattaaacacctactatgtgctgggctttgtgctcaggcctttacctcctacccttgaagatctcagagtctaatggagaagaatgcttc
Downstream sequence
caatgtagtgggaaaaatagacatagaaggaaataattagagataagactggaagggctaatagaagaatggtagagagtgctatgagacttccgaagag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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