Basic Information
VIS ID
TVIS44003724
Fusion event
HTLV-1-RUBCNL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.13
Reference genome
GRCh37/hg19
Start
46948326/46374191 (Hg38)
End
46948326/46374191 (Hg38)
Orient
-
Location type
Intronic
Target gene
RUBCNL
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-1257 ; hsa-mir-1296-5p ; hsa-mir-1915-3p ; hsa-mir-2909 ; hsa-mir-4253 ; hsa-mir-4436b-3p ; hsa-mir-4632-5p ; hsa-mir-4726-3p ; hsa-mir-4761-3p ; hsa-mir-6716-5p ; hsa-mir-6735-5p ; hsa-mir-6764-5p ; hsa-mir-6840-3p ; hsa-mir-6862-5p ; hsa-mir-6879-5p ; hsa-mir-7113-5p ; hsa-mir-7843-5p
Nearest miRNA
hsa-mir-2276/Upstream/2177991; hsa-mir-1267/Downstream/3622224;
Nearest TSS
ENST00000623511/Upstream/23184; ENST00000612699/Downstream/4454;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/321307, chr13-CpG: 93/Downstream/12358
Upstream sequence
ccaatagatttctctgctgttactcttgcccaggctggagtgcagtggcacaatctcggctcactccaacctctgcctcccaggttcaagcagttctctg
Downstream sequence
cctcagcctcccaagtagctgggattacaggtgcatgccaccacacccagctaatttttgtatttttaacagagacggggtttcaccatgttggccaggc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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