Basic Information
VIS ID
TVIS44003738
Fusion event
HTLV-1-KCNJ12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
21280967/21377655 (Hg38)
End
21280967/21377655 (Hg38)
Orient
-
Location type
Intronic
Target gene
KCNJ12
miRNAs that regulate target gene
hsa-mir-6802-3p ; hsa-mir-5189-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6752-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-5694 ; hsa-mir-383-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-5689 ; hsa-mir-4485-5p ; hsa-mir-4789-3p ; hsa-mir-642a-3p ; hsa-mir-642b-3p
Nearest miRNA
hsa-mir-1180/Upstream/2033081; hsa-mir-10226/Downstream/5916255;
Nearest TSS
ENST00000595228/Upstream/1458; ENST00000331718/Downstream/27481;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/246, chr17-CpG: 96/Downstream/37683
Upstream sequence
TCCCAGGGTTTCAGGGCCAGGGTCCACCCTGCGCGCGCACGGCCTCTCCGGGTGCCCTGGGGGAGCGGGGCGGGAATCAGGGGCTCATGGGCAGAGACAG
Downstream sequence
CTGGGGTGGGGCGCTCCTTGGGGGGTTCAGATGGGAGTTGAGGCCCAAGCGAGTGTCTGTGCCTCGGTTTTGATCCAGCGTGCCCATGTCATGTGAATAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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