Basic Information
VIS ID
TVIS44003750
Fusion event
HTLV-1-SGSM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
25203161/24807194 (Hg38)
End
25203161/24807194 (Hg38)
Orient
-
Location type
Intronic
Target gene
SGSM1
miRNAs that regulate target gene
hsa-mir-760 ; hsa-mir-221-5p ; hsa-mir-6848-3p ; hsa-mir-3187-3p ; hsa-mir-6843-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-3663-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-4781-3p
Nearest miRNA
hsa-mir-1286/Upstream/1920815; hsa-let-7a-3/Downstream/648452;
Nearest TSS
ENST00000624155/Upstream/875; ENST00000480523/Downstream/36266;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/608, chr22-CpG: 147/Downstream/144990
Upstream sequence
ATCAGAGAGGTTCTGCCATTCCTCTGCCCCTCCACTCTCCTTGGGGTCAGCGCGTGGAGAGGGGGGCAGTCTAGTCTTTAGGGCTCATGGCCAATGACCT
Downstream sequence
CCCAGAACCCCATAGACAGAATTTATAGTCCTTGGGGTAGCATCTCGATGCCTGGACTGCGTGCTCTGGTGTGTATACCTGCATGGGTGAGGACCTGTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate