Basic Information
VIS ID
TVIS44003755
Fusion event
HTLV-1-PALLD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
169837066/168915915 (Hg38)
End
169837066/168915915 (Hg38)
Orient
-
Location type
Exonic
Target gene
PALLD
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-196a-5p ; hsa-mir-218-5p ; hsa-mir-6869-5p ; hsa-mir-610 ; hsa-mir-4717-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-1298-5p ; hsa-mir-656-5p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-3162-3p ; hsa-mir-1250-3p ; hsa-mir-483-3p ; hsa-mir-4775 ; hsa-mir-4694-5p
Nearest miRNA
hsa-mir-12113/Upstream/3529578; hsa-mir-1305/Downstream/2270269;
Nearest TSS
ENST00000502981/Upstream/17356; ENST00000503290/Downstream/5660;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/37441, chr4-CpG: 66/Downstream/93724
Upstream sequence
TTAAGAAAACAGATGACTAAAAGTCTGGAAGTAACTACTATCTATATTTCTATCTATCTGTCATCTTTCTTGTTTCAAGGCCTCGTTCTAGATCAAGGGA
Downstream sequence
CAGTGGAGACGAAAATGAACCAATTCAGGAGCGATTCTTCAGACCTCACTTCTTGCAGGCTCCTGGAGATCTGACTGTTCAAGAAGGAAAACTCTGCAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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