Basic Information
VIS ID
TVIS44003762
Fusion event
HTLV-1-TOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
59790019/58877460 (Hg38)
End
59790019/58877460 (Hg38)
Orient
-
Location type
Intronic
Target gene
TOX
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-124-1/Upstream/15981185; hsa-mir-10400/Downstream/2837328;
Nearest TSS
ENST00000518652/Upstream/217616; ENST00000523683/Downstream/241580;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/217493, chr8-CpG: 175/Downstream/240115
Upstream sequence
CAGACAAGAAAATAAAAGCATAAATGTTGCTAGTTATAGTAGCACCAGAGGGAATGTGTGGTCCCGCACAAAATTGTGCTTCCTCAATTCTGAATTGGCA
Downstream sequence
CACTTGACTTAGAATAAATGTATTCACTTTCTCGATCTTGTGAAATAGAGACTCAACAAGACTTCTTAATAACCCTCCAACCTTGCCTGCTGTTTGCACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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