Basic Information
VIS ID
TVIS44003789
Fusion event
HTLV-1-ZNF583 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
56927633/56416264 (Hg38)
End
56927633/56416264 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF583
miRNAs that regulate target gene
hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-20a-3p ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-186-5p ; hsa-mir-513b-5p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-1910-5p ; hsa-mir-455-3p ; hsa-mir-216b-5p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-665 ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-3664-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-4695-5p ; hsa-mir-510-5p ; hsa-mir-6768-5p ; hsa-mir-34b-3p ; hsa-mir-5690 ; hsa-mir-512-5p
Nearest miRNA
hsa-let-7e/Upstream/1028022; hsa-mir-10394/Downstream/1918424;
Nearest TSS
ENST00000633603/Upstream/11908; ENST00000585612/Downstream/6886;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11777, chr19-CpG: 148/Downstream/60680
Upstream sequence
aaaatacaaaaattagccaggtgtggtggcaggctcctgtaatcccagctacttaggaggctgaggcagagaatcacttgaactcaggaggtggaggttg
Downstream sequence
cagtgagctgagattgcaccactgaactttagcctgggagacagagtgagactccgtctcaaaaaaaaaaaaaaaaaagaatacatttattaggttgctc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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