Basic Information
VIS ID
TVIS44003793
Fusion event
HTLV-1-PRPF40A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
153573860/152717346 (Hg38)
End
153573860/152717346 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PRPF40A
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-34a-5p ; hsa-mir-32-5p ; hsa-mir-455-3p ; hsa-mir-5011-5p ; hsa-mir-4776-3p ; hsa-mir-5006-5p ; hsa-mir-3972 ; hsa-mir-1202 ; hsa-mir-190a-3p ; hsa-mir-5689 ; hsa-mir-1-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-5700
Nearest miRNA
hsa-mir-128-1/Upstream/1348935; hsa-mir-10b/Downstream/6469489;
Nearest TSS
ENST00000437798/Upstream/1216; ENST00000425034/Downstream/27;
Nearest CpG islands
chr2-CpG: 169/Target, None/Upstream, None/Downstream
Upstream sequence
GGAAGCCGTCAGCAGAGACCCAAGAGCCGGAGCAGAGGCTTGAGCCGGACAATCTCCGCTCCCCGTCCCCAGGACCCTGCGAGGGAGGATGGCTCTCCAT
Downstream sequence
TTCACTCACCATGAGGCCTCCACGCTCAGCTCCCGTCCCCGGCCTCATCGTCGGGCTCAGACTGCTCCGCCGGCGGCCACTGCCGCTACACATACCAACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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