Basic Information
VIS ID
TVIS44003794
Fusion event
HTLV-1-MAP3K20 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
174019235/173154507 (Hg38)
End
174019235/173154507 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
MAP3K20
miRNAs that regulate target gene
hsa-mir-874-3p ; hsa-mir-6807-5p ; hsa-mir-146b-3p ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-7976 ; hsa-mir-4749-3p ; hsa-mir-210-5p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6752-3p
Nearest miRNA
hsa-mir-128-1/Upstream/4571489; hsa-mir-10b/Downstream/2013126;
Nearest TSS
ENST00000437798/Upstream/63888; ENST00000480606/Downstream/5503;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/77964, chr2-CpG: 86/Downstream/200298
Upstream sequence
tcctgacctcaggtgatccacctgcctcagcctcccaaagtgctggtattataggcatgagccaccgtgcccagccTAATCCATTCTTCATGGTCTAGTT
Downstream sequence
GACACTGTCCATTACCTCCCAACTTCCCTAATTTTAATACAGATCCTTCACGTGTTTTGTACTTCTGATGGTTGTTATGTGGCATCTTGTTAATAGGTAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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