Basic Information
VIS ID
TVIS44003808
Fusion event
HTLV-1-COQ2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.23
Reference genome
GRCh37/hg19
Start
84153654/83232501 (Hg38)
End
84153654/83232501 (Hg38)
Orient
+
Location type
Intronic
Target gene
COQ2
miRNAs that regulate target gene
hsa-mir-99a-5p ; hsa-mir-93-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-12113/Upstream/479071; hsa-mir-1243/Downstream/2489967;
Nearest TSS
ENST00000502981/Upstream/95426; ENST00000512375/Downstream/14712;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/122345, chr4-CpG: 71/Downstream/51727
Nearby gene
COQ2(-31323) ;
Upstream sequence
TGAAGACTGATTAATTAAGATGTCATTCATGACATGGTGAGCCATCTTGAGATATTTGAATATCCTGCCACCATGGGAACCCAGACCTACCTCTGGACTA
Downstream sequence
ATTATTGGGAGGGGATTGTGGGAAAGAATAATGACTGGGAAATAGAAATCTTTAAGATGCTCTTGAGCAGAACAAATTTCTCCTCCAATAAAGATGTCCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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