VISDB - VIS Detail

Basic Information

VIS ID

TVIS44003812

Fusion event

HTLV-1-CDKAL1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr6

Cytoband

p22.3

Reference genome

GRCh37/hg19

Start

20561041/20560810 (Hg38)

End

20561041/20560810 (Hg38)

Orient

Location type

Intronic

Target gene

CDKAL1

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-98-5p ; hsa-let-7e-5p ; hsa-mir-1273e ; hsa-mir-887-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-1282 ; hsa-mir-5707 ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-890 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6089 ; hsa-mir-6499-5p ; hsa-mir-5693 ; hsa-mir-500a-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-3162-5p ; hsa-mir-4266 ; hsa-mir-7154-3p ; hsa-mir-1288-3p ; hsa-mir-202-3p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-7162-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-3169 ; hsa-mir-6840-3p ; hsa-mir-4459

Nearest miRNA

hsa-mir-3691/Upstream/1988930; hsa-mir-10398/Downstream/6586816;

Nearest TSS

ENST00000381078/Upstream/14469; ENST00000476517/Downstream/239884;

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/157258, chr6-CpG: 131/Downstream/1026380

Upstream sequence

AGCATATGTTTGATGGTTAAGGGGGAAGTGATTTGAATATCTCAGGATTTGCAGAGACTTTGCTTTTACCTCTTCTTTCATTGTAGCTTGGTCATTCTCA

Downstream sequence

AATTTGAGTTTCTAAGGACTTTTAAAGTGTTACGTATGCTAATCCATGTATACATTATTTTTATGATTGATTAAGGACTTTTTTGGGAAGAGTTGTGGCT

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.