VISDB - VIS Detail

Basic Information

VIS ID

TVIS44003817

Fusion event

HTLV-1-SCAI integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr9

Cytoband

q33.3

Reference genome

GRCh37/hg19

Start

127887896/125125617 (Hg38)

End

127887896/125125617 (Hg38)

Orient

+

Location type

Intronic

Target gene

SCAI

miRNAs that regulate target gene

hsa-mir-1273e ; hsa-mir-6771-5p ; hsa-mir-873-5p ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-302f ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-4758-3p ; hsa-mir-4537 ; hsa-mir-4286 ; hsa-mir-3651 ; hsa-mir-6769a-3p ; hsa-mir-3943 ; hsa-mir-4323 ; hsa-mir-625-5p ; hsa-mir-129-5p ; hsa-mir-3149 ; hsa-mir-411-5p

Nearest miRNA

hsa-let-7a-1/Upstream/431819; hsa-mir-12126/Downstream/2565070;

Nearest TSS

ENST00000422679/Upstream/121927; ENST00000416065/Downstream/17870;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/184082, chr9-CpG: 70/Downstream/17416

Upstream sequence

actccatctccaaaaaaaaaagaaagaaaaataaaaCTGAACTGCCCTTTAATCAAAAGATATCTGCTTCTTAaggccaaggtgggtgaatcacctaagg

Downstream sequence

tcaggagtttgagatcagcctggccaacatgacaaaaccctgtgtctacaaaaaatacaaaaaaatcagccacgcatggtggcaggcactgtaatcccag

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.