VISDB - VIS Detail

Basic Information

VIS ID

TVIS44003855

Fusion event

HTLV-1-ITIH5 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr10

Cytoband

p14

Reference genome

GRCh37/hg19

Start

7701653/7659690 (Hg38)

End

7701653/7659690 (Hg38)

Orient

+

Location type

Intronic

Target gene

ITIH5

miRNAs that regulate target gene

hsa-mir-29a-3p ; hsa-mir-6809-3p ; hsa-mir-491-3p ; hsa-mir-4753-3p ; hsa-mir-340-5p ; hsa-mir-2117 ; hsa-mir-586 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-640 ; hsa-mir-433-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-5088-3p

Nearest miRNA

hsa-mir-3155a/Upstream/1507413; hsa-mir-107/Downstream/4471070;

Nearest TSS

ENST00000439456/Upstream/18911; ENST00000473227/Downstream/7281;

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/79703, chr10-CpG: 49/Downstream/7016

Upstream sequence

CTCTCAGGTATTAAGTTCCCTGATTGATCTAAAGTATTTTCTTTGAAGTTTTCTCTTTTGTAAAATAGGTTTTCTGAGAAAATAAGCATGCTTCAAGGAG

Downstream sequence

AACAAGAGAAGCTGGTTTTTCATTTTTGAGATGCCTATCTGATGTCTCAGGGGATCACTATGGCCACACTTCAGTCCAAGTTTCAACTCAGCTTGACCCA

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.