Basic Information
VIS ID
TVIS44003856
Fusion event
HTLV-1-ST6GAL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
107498640/106882184 (Hg38)
End
107498640/106882184 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
ST6GAL2
miRNAs that regulate target gene
hsa-mir-5192 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-7153-5p ; hsa-mir-185-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-3925-5p ; hsa-mir-15b-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-125a-3p ; hsa-mir-3529-3p ; hsa-mir-552-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/4449818; hsa-mir-10b/Downstream/2259306;
Nearest TSS
ENST00000437798/Upstream/47720; ENST00000443833/Downstream/3829;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/38758, chr2-CpG: 196/Downstream/3713
Upstream sequence
GTTGCAGCTTAAAACCTTTTCTGCTTCCAGGTTCTGATGAACACATGCTTTCTGTATACATGGGCTCCCTGACATCCTCTTCCATCATATACAATCTTCC
Downstream sequence
CCATCCAGCAGGCTCAGCCTGATTTGAGGACATGAAAACTGATAGTCTTAGTTGGTCTCTGGCCCCACACAATTACAGGAGTTGTCATTCTTGTTTTCCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate