Basic Information
VIS ID
TVIS44003859
Fusion event
HTLV-1-RAPGEF5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
22310749/22271130 (Hg38)
End
22310749/22271130 (Hg38)
Orient
+
Location type
Intronic
Target gene
RAPGEF5
Nearest miRNA
hsa-mir-1183/Upstream/799984; hsa-mir-10399/Downstream/3678789;
Nearest TSS
ENST00000635602/Upstream/50892; ENST00000435127/Downstream/20111;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/187777, chr7-CpG: 90/Downstream/85290
Upstream sequence
ATCTTTTTCTCATGTTTCTTCTTTCCCAATTGCTATTTGGTCACTACTTTTGGTCTACTTACTGGGAAATGCTTTCTTTAAATAGCTTGAGTTTTCATCT
Downstream sequence
AGTTcagcagttctcaaacttgactgcacattagaatcatttggagaggtttaaaaaaaatactgatatttaggccccaactaaatcagaatctcgggat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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