Basic Information
VIS ID
TVIS44003861
Fusion event
HTLV-1-VSTM4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
50235126/49027081 (Hg38)
End
50235126/49027081 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
VSTM4
miRNAs that regulate target gene
hsa-mir-1206 ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-2276-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6890-3p ; hsa-mir-1321 ; hsa-mir-3126-3p ; hsa-mir-3128 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-4524a-3p ; hsa-mir-4720-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4799-3p ; hsa-mir-5588-5p ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-6868-5p ; hsa-mir-6873-5p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-1285-5p ; hsa-mir-129-5p ; hsa-mir-1304-3p ; hsa-mir-153-5p ; hsa-mir-216a-5p ; hsa-mir-3672 ; hsa-mir-4639-3p ; hsa-mir-6794-3p ; hsa-mir-6864-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-1265/Upstream/41494; hsa-mir-107/Downstream/2272492;
Nearest TSS
ENST00000439456/Upstream/42517; ENST00000435809/Downstream/50210;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/370525, chr10-CpG: 77/Downstream/88058
Upstream sequence
TTAAGTTGATCCCCTCCGCATGAAACTCTTGCCTGTCACACACAAGGTGGACCCCTACTCCTTCAAAACCCACCAGGCCCTCTGAATGCCCTGACACTGA
Downstream sequence
TGCCATTGGCGGCCACACTCTCCTGCACTCACTGCACCTGTGATTTCCTCTGACCCTGCACAGCGAGCTACTGGGATTCTGCCTCGCCCTCTCTAATGAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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