Basic Information
VIS ID
TVIS44003876
Fusion event
HTLV-1-PDS5B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
33166045/32591908 (Hg38)
End
33166045/32591908 (Hg38)
Orient
-
Location type
Intronic
Target gene
PDS5B
miRNAs that regulate target gene
hsa-mir-27a-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-2276/Upstream/8429404; hsa-mir-1267/Downstream/7072126;
Nearest TSS
ENST00000623511/Upstream/5339; ENST00000481616/Downstream/109076;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/4210, chr13-CpG: 157/Downstream/423882
Nearest cancer related gene
PDS5B(TSG, No orient, 0)
Upstream sequence
CCACCACCTACCTTCACCCTTACCTAAGAGCTAAGATGGTCTGAGAGAAGTGGGACTTTAAGAAGAGGAAAAATATTTTGGGGCTCATGGCACCTTGACG
Downstream sequence
GGGAGCAATGCTCTGAATGGAGAGGCTACAGCACCTGGCTTTGAACAACTCTGGGTCAGTATGAGAGTATTGAAAGCCCTTGACTTGGTGTAAACATAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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