Basic Information
VIS ID
TVIS44003877
Fusion event
HTLV-1-PELI2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
56653958/56187240 (Hg38)
End
56653958/56187240 (Hg38)
Orient
-
Location type
Intronic
Target gene
PELI2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-151a-5p ; hsa-mir-222-3p ; hsa-mir-498 ; hsa-mir-377-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-34b-3p
Nearest miRNA
hsa-mir-208a/Upstream/1309047; hsa-mir-1185-1/Downstream/3459722;
Nearest TSS
ENST00000550708/Upstream/68131; ENST00000612106/Downstream/118598;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/67724, chr14-CpG: 41/Downstream/392514
Upstream sequence
tGTTGCTGCAGATGGCAGGTAGAAAATATTCTGAAGGATAAGACCAAAGCTGGGTTCTGCTCCTCATTTTTCCACGTTTCTATACTGTGAATTGGGAAAT
Downstream sequence
TTATTCATCTCCAAACTAGAATGCTGCAACCCTAAAATAAGTGAATATGATATTTGCCAATAAAAATGGAAGTTGCCTTGTAGACCTACAAGGGACAAGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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