Basic Information
VIS ID
TVIS44003912
Fusion event
HTLV-1-TRIO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
14273170/14273061 (Hg38)
End
14273170/14273061 (Hg38)
Orient
+
Location type
Intronic
Target gene
TRIO
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-32-5p ; hsa-mir-30a-5p ; hsa-mir-93-3p ; hsa-let-7a-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-10397/Upstream/3794916; hsa-mir-103a-1/Downstream/552868;
Nearest TSS
ENST00000502646/Upstream/89263; ENST00000504606/Downstream/17916;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/127820, chr5-CpG: 37/Downstream/187982
Nearest cancer related gene
TRIO(OG, No orient, 0)
Upstream sequence
tcacatactctaaaatccacctttttaaaacgtgtgattcagtggattttagtgtatcaccaggttgtgcaactgttaccactaattccagaaccttttc
Downstream sequence
atcacctcccaggaaccccatatccacccccaagcccccagcactggcaatcactaatttactttctgctctGACCCCATTTTAAAAAATATTAGGGAAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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