VISDB - VIS Detail

Basic Information

VIS ID

TVIS44003913

Fusion event

HTLV-1-UGT3A1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr5

Cytoband

p13.2

Reference genome

GRCh37/hg19

Start

35954205/35954103 (Hg38)

End

35954205/35954103 (Hg38)

Orient

+

Location type

UTR3

Fragile sites / regions

FRA5A

Target gene

UGT3A1

miRNAs that regulate target gene

hsa-mir-181a-5p ; hsa-mir-498 ; hsa-mir-513b-5p ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-3156-5p ; hsa-mir-6715b-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-4272 ; hsa-mir-4802-3p ; hsa-mir-4680-3p

Nearest miRNA

hsa-mir-10397/Upstream/3559628; hsa-mir-103a-1/Downstream/193789;

Nearest TSS

ENST00000502646/Upstream/15281; ENST00000513263/Downstream/37231;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/335866, chr5-CpG: 85/Downstream/197292

Upstream sequence

CAAGTCACAAGGGGCAAGTCAAGAAGCCTCAGTGGTGCGTGAAGATTTCTAAACAGAGGCAGAGAATAGAAAGAAGCAAGTTGCAGGATCAGTGGCAGGT

Downstream sequence

GGAGCTGAAGAGAGAACAGAGGGGTGGCGTGTGCTGGGGTGGGGAGAACCTTCAAAGGACCAGGGATGCCCTCCCCTCACCCAAGGCTACACCTAGCCTC

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.